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6 pages/≈1650 words
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Health, Medicine, Nursing
English (U.S.)
MS Word
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Pernicious Anemia

Teri goes to see her PCP after feeling depressed last couple of months as well as experiencing a seizure earlier this week. The physician orders a few test, results are shown below: Low hematocrit Low levels of Vit B12 Low Oxygen levels Presence of autoantibodies against the parietal cell Peripheral blood smear shows abnormal RBC (large pale RBCs) After viewing the results, Teri is diagnosed with Pernicious Anemia; a condition in which autoantibodies destroys the parietal cells found within the stomach. Address each of the following regarding Teri’s case: Since the parietal cell is destroyed, which substance(s) is Teri lacking as a consequence? What is the correlation between destruction of parietal cells and Vit B12 deficiency? Due to her condition, Teri lacks Pepsin. Explain why. If Teri were healthy, explain what her RBCs would look like? What is hematocrit? Low oxygen levels stimulate her body to create new RBCs by stimulating which process? Explain that process in depth. What protein transports oxygen in our body and explain its structure? What cell secretes antibodies and explain the various functions of antibodies. What are the different types of antibodies and give two characteristics for each? Explain the structure of an immunoglobulin. Specifics: Support your opinions with evidence from your readings and research. You must reference a minimum of three (3) scholarly sources in your paper, which includes one non-Internet source. Use current APA Style to format your paper and to cite your sources. Your paper/total responses must be 3– to 4-pages in length not including the title page, abstract, and reference pages. Title page: Case Title, Full Name, Section, Date, Instructor and Campus Abstract: Summarize the case in a paragraph Introduction: The physiological importance of the digestive system, immune system, and cardiovascular system for the proper functioning of the human body Body: Organize your analysis with headings that thoroughly answer the prompts Conclusion: Summarize the paper in a paragraph See rubric for specific grading criteria.

Pernicious Anemia




Campus abstract


The digestive system is a system that initiates breaking down nutrients from fluids and food ingested and absorbing the nutrients. This helps in essential activities in the body such as the development and repairing of cells. However, the system has six main functions which are; food ingestion in the mouth, aids in the production of digestive enzymes and fluids, assists in the mixing of food and transporting them all through the body, breaking down bigger particles of food into simpler food particles, helps in the absorption of nutrients and finally aids in the removal of waste from the body (Svihus&B.,2014). Moreover, the immune system serves a crucial purpose in the human body. It is a system that shields one’s body from pathogens, harmful substances, and cell changes that can make one sick. In addition to this, there is a vital system in the human body called the cardiovascular system. It comprises the heart, blood vessels, and blood. The cardiovascular system's main functions are; to facilitate transportation of nutrients, transportation of blood rich in oxygen to all parts of the body, and transport the deoxygenated blood from body parts to the lungs.

Which substances did terry lack causing pernicious anemia?

Pernicious anemia is an autoimmune disease that affects the gastric mucosa damaging the absorption of vitamin B12 causing vitamin B12 deficiency in the body. The main purpose of vitamin 12 is for the production of blood cells and myelination of nerves. The deficiency of vitamins B12leads to a disorder called megaloblastic anemia. However, pernicious anemia is an example of megaloblastic anemia. Megaloblastic anemia is caused by intrinsic factors. This is a glycoprotein that holds up cobalamin consequently making it possible to be absorbed by the terminal ileum. The autoimmune initial of pernicious anemia is therefore supported by parietal cells and intrinsic factors of autoantibodies later causing autoimmune disorders. Diagnosis of this disease is key since it can bring some complications later on. Its symptoms are diverse and tricky at the commencement of the includes general weakness, fatigue, paresthesia, whiteness, and lack of self-control. The disorder may relate to other autoimmune diseases or maybe genetic generated.

What is the correlation between the destruction of parietal cells and vitamin B12?

Parietal cells are cells found in the stomach that is responsible to produce hydrochloric acid and intrinsic factors. They are deep and infoldings to provide a large surface area for maximum production of hydrochloric acid. Intrinsic factor is the production of a glycol protein by the parietal cells which are found in the fundus and the gastric body. Inadequacy of the intrinsic factor leads to destructive homeostatic behavior. Notably, intrinsic factors are responsible for transporting and absorbing a crucial nutrient which is vitamin B12 by the terminal ileum. Additionally, this homeostatic change may lead to neurological and neutropenia disorders. In some cases, it may lead to a serious cardiovascular disorder. As we have stated previously is that pernicious anemia is caused by vitamin B12 deficiency. The release of the vitamin relies highly on the pH that is the acidic surrounding. Consequently, the mass destruction of a parietal cell causes significant loss of acid in the stomach and vitamin B12 absorption. Due to the lack of vitamin B12, it c

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