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2 pages/≈550 words
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Biological & Biomedical Sciences
Article Critique
English (U.S.)
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Is the development of high-grade gliomas sulfur-dependent? - Review (Article Critique Sample)

This was an article critique of the journal entry by wrobel et al., "Is the development of high-grade gliomas sulfur-dependent" The relationship between the availability of sulfur and the growth of high-grade gliomas was explored source..
Is the development of high-grade gliomas sulfur-dependent? - Review Name Institution Is the development of high-grade gliomas sulfur-dependent? - Review Sulfane sulfur accumulation is important for the proliferation of malignant cells, as well as for tumor growth (Wrόbel et al., 2014). The researchers investigated the link between sulfur and the development of high-grade gliomas in the brain. This relationship was probed by assaying the activities of rhodanese, 3-mercaptopyruvate sulfurtransferase and γ-cystathionase within different parts of the human brain. The thalamus, hippocampus, sub-cortical nuclei, hypothalamus, cerebellum and the cortex were characterized in the study. The study was done using human gliomas with a malignancy grade ranging from I to IV (Wrόbel et al., 2014). The experiment proved that there is indeed a link between sulfur accumulation and the development of high grade gliomas. This outcome is in harmony with the methodical determinations of the target enzymes in the brain. Because the link between high grade gliomas and sulfane sulfur accumulation is evident, future research has to take this into consideration with regards to developing pharmacologically dynamic anti-tumor drugs. Sulfur ranks as one of the most important non-metallic elements fundamental to life. In biological systems such as the human body, sulfur can be found in a variety of oxidation states. Sulfane sulfur plays the most important role in biological processes. The destiny of sulfane sulfur in the body is not expected, as a matter of fact, it is not acknowledged if it has a significant role in the body. In elevated quantities, sulfane sulfur is a broad-spectrum poison. This means that it is able to poison various systems in the body: the nervous system is the most affected body system. Because of its innate existence in the body, there are several enzymes that can oxidize it to harmless sulfate. In the brain, sulfane sulfur enhances NMDA receptor response, thus facilitating long-term potentiation. As such, it is involved in the process of memory formation. In the long run, it is altered to sulfite by thiosulfate reductase in the mitochondria. These sulfates are then excreted in urine. Generally, this is an excellent study, it is very compelling. The researchers stated facts that were backed up with thorough research and in depth documentation. The hypothesis and arguments presented were well thought out and properly noted. It is imperative to note that the researchers used recent research methodology coupled to up to date data analysis techniques. All the listed facts were supported with clear and concise research and an extensive literature review. The structure of the publication adhered to all the stipulated rules regarding the use of citations. The effort displayed in dealing with complex issues related to gliomas and tumor cell formation is worth noting. Onto the structure and overall organization of the article, the publication has good points, nonetheless, the reader may at times get lost in the article. This is mostly when trying to keep up with the rate at which the result...
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