Analysis of Paracetamol (Essay Sample)

DECLARATION
I, Samson Cheruiyot Mutai, hereby declare that this proposal is my original work and that it has not been submitted before for any academic award and for either any academic award either in this or other institutions of higher learning for academic publication or any other purpose.
Signature…………………. Date…....
SUPERVISOR
I confirm that the candidate under my supervision has developed this proposal.
Signature….... Date …………………………
Professor Ombaka
DEDICATION
I dedicate this research proposal to my parents Mr. and Mrs. Joseph Langat and my cousin Miss Faith for their continued support, encouragement, for my education and their courage in me. To my mentors Richard Feyman, Mary Curie and Albert Einstein (Historical Scientist) special thanks for your inspiration and support throughout my life. Finally, to all my friends, you are my best. God bless you all.
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ABSTRACT
Paracetamol is the most common and widely used medicine for the treatment of pain and fever. the chemical name for Paracetamol is P-acetyl-N-aminophenol. It is involved in the production of prostaglandins, which aid in the dilation of blood vessels that induce headache discomfort. Excessive paracetamol in suspension can harm the liver. Some students in Kenya and India conducted research relating to paracetamol, but this was just dealing with quality assessment of some brand tablets. The goal of this study is to demonstrate the need for market surveillance for brand paracetamol suspension registered in Kenya in order to ensure that only high-quality suspension are sold both within and beyond the nation and also for chemical equivalency and bioavailability. British Pharmacopeia will be use as reference for all analysis that will be experimented. The sample will be collected from community pharmacy or chemist around Chuka town randomly and sample size will be calculated using statistical equation. The paracetamol suspension will be identified using a UV- VIS detector, and different brands will be tested and content of active pharmaceutical will be calculated and compared with label claims and find if they are within tolerance. Any defects discovered will be reported to National Pharmacy and Poison Board for implementations of Good Manufacturing Practices to companies that have such defects. Market surveillance is critical for judging the quality of various brands of paracetamol suspension, as well as for narrowing the problem relating to high content of active component concentration in the suspension and improvement of the market of Kenya made paracetamol by improving its quality.