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2 pages/≈550 words
4 Sources
Health, Medicine, Nursing
Article Critique
English (U.S.)
MS Word
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Critically review Paper by Wakefield et al (Article Critique Sample)


Critically review the following controversial paper published (and later retracted) by Wakefield et al, which implicated MMR vaccine as a possible etiologic contributor to Autism, etc. You may use either version for your review. Describe potential sources of bias and other limitations in the study: Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children A J Wakefield, S H Murch, A Anthony, J Linnell, D M Casson, M Malik, M Berelowitz, A P Dhillon, M A Thomson, P Harvey, A Valentine, S E Davies, J A Walker-Smith The Lancet, Volume 351, Number 9103 28 February 1998 Pro 7 Con Arguments: “Should any vaccines be required for children? Retrieved from on November 5, 2013


Wakefield is an outstanding medical professional researcher, who alongside other researchers has conducted various research activities that are of great benefit to the field of medicine. He is a leading researcher whose controversial findings have led to various opinions from the stakeholders in the medical activities as well as the general public. This paper critically reviews the first paper that was published in 1998. It aims at establishing the flaws that are evident to help in facilitating a clear understanding of the facts that the researchers failed to consider throughout their research activities.
Wakefield and colleagues undertook a research activity that led to the publishing of a paper titled "Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children.” They came up with a hypothesis that asserted that MMR vaccine is responsible for causing a series of events that include loss of intestinal function, intestinal inflammation, entrance of encephalopathic into the blood stream, and consequent development of autism. In support of their hypothesis, they described a total of 12 children who had neurodevelopment delay where 8 of them had autism. According to Wakefield et al. (1998), all these children covered by the study had gastrointestinal complaints that were taught to have been developed within one month of receiving MMR.
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