Effects of Alpha-2 Adrenergic Agonists Treatment (Essay Sample)

Effects of Alpha-2 Adrenergic Agonists Treatment
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Effects of Alpha-2 Adrenergic Agonists Treatment
The human brain is one of the most sensitive constituents of the human body. Diseases affecting the brain are normally complex to cure which calls for specialized treatment. Alpha-2 Adrenergic Agonists may have significant applicability in combating deficits in the pre-frontal cortex in humans as well as treating individuals with dysfunctional behaviors. This essay seeks to discuss the effects of administering Alpha-2 Adrenergic Agonists on regional cerebral blood flow (rCBF) in humans. Specifically, the essay will evaluate the effects of administering Alpha-2 Adrenergic Agonists treatment on normal groups, individuals suffering from frontal lobe epilepsy (FLE), and individuals suffering from temporal lobe epilepsy (TLE).
One of the notable effect of Alpha-2 Adrenergic Agonists treatment during normal group is that it leads to both a decrease and increase in regional cerebral blood flow (rCBF). The increase particularly affects the cortices, both frontal as well as parietal (1). This increase is more pronounced on the pre-motor section on superior, mid-frontal as well as pre-central partitions of the gyrus. On the other hand, the decreases are more pronounced on the hemispheres on the posterior side and the perisylvian on the right part of the body. Specifically, the decrease is more pronounced in the left gyrus, the posterior cortex, and the transverse gyrus.
When the Alpha-2 Adrenergic Agonists treatment is administered to individuals with Temporal Lobe Epilepsy (TLE), it is observed that rise in rCBF is most pronounced on the frontal gyrus. The decrease in rCBF is most pronounced in the lower hemispheres at the posterior side particularly the Maximal as well as the Vermis. However, there is an insignificant increase in the frontal gyrus (2). When the Alpha-2 Adrenergic Agonists treatment is administered in rest control, the results are significantly different. Here, it is noted that the decrease in rCBF is more pronounced in the occipital region. Notably, though there are insignificant increases, the parietal region exhibits some significant increase
When the Alpha-2 Adrenergic Agonists treatment is administered to the test group exhibiting Frontal Lobe Epilepsy (FLE), it is noted that increase in rCBF is only evident in the bilateral temporal parts of the body and the gyrus exhibiting the cingulate pattern (3). Specifically, it is noted that the anterior increase in rCBF supersedes the posterior increase. Notably, Maximal is significant at the middle part of the temporal gyrus covering both the insular and the cingulate at the right side of the body. Notably, there are minimal decreases on the posterior side. However, there is significant rCBF decrease in the prefrontal cortex.
Conclusion
When the Alpha-2 Adrenergic Agonists treatment is administered to the normal grou...